解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The impact of major histocompatibility class I chain-related A (MICA) antibodies on renal graft outcomes is unclear. The goal of this work was to assess the impact of posttransplant MICA antibodies, assayed at 1 year, with two commercially available kits, on long-term renal graft outcomes. METHODS:We retros...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e31824fd8f1
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824fd8b4
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for blood product transfusions. During the last decade, improved surgical and anesthetic management has reduced intraoperative blood loss and blood product transfusions. A first report from our group published in 20...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318250fc25
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis of AKI, accurately discriminating acute allograft rejection from other ca...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0b013e31824fd892
更新日期:2012-06-27 00:00:00
abstract::Israel's rates of organ donation have been one of the lowest among developed countries. An attempt to change this has led to the introduction of a pioneering new law, the Organ Transplant Act 2008, which came into effect in January 2010 and sets out principles underlying a new policy in relation to the allocation of o...
journal_title:Transplantation
pub_type: 社论
doi:10.1097/TP.0b013e31824e3d95
更新日期:2012-05-27 00:00:00
abstract:BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824cd59d
更新日期:2012-05-15 00:00:00
abstract:INTRODUCTION:Posttransplant anemia and its association with transplant outcomes have not been properly studied. METHODS:We examined 530 renal allograft recipients transplanted at our center and followed up for 31.0±14.1 months. Hemoglobin (Hb), serum bicarbonate, and creatinine; use of erythropoiesis-stimulating agent...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824b36fa
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:Early calcineurin inhibitor (CNI) withdrawal with mycophenolate mofetil (MMF) has not become routine practice, due to concerns about excess acute rejection. Therapeutic drug monitoring may be advantageous when the CNI or MMF is withdrawn. METHODS:This prospective, randomized, concentration-controlled withdr...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31824ad60a
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:Anemia after kidney transplantation has been associated with poor transplant outcomes. We hypothesized that intravenous (IV) iron may more rapidly correct anemia than oral (PO) iron. METHODS:One hundred four kidney transplant recipients were prospectively randomized to IV iron polymaltose (500 mg single dos...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e318248375a
更新日期:2012-04-27 00:00:00
abstract::The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...
journal_title:Transplantation
pub_type: 历史文章,杂志文章
doi:10.1097/TP.0b013e3182483713
更新日期:2012-04-27 00:00:00
abstract::India with a population of 1.2 billion has a renal transplantation rate of 3.25 per million population. The major cause of chronic kidney disease is hypertension and diabetes. The crude and age-adjusted incidence rates of end-stage renal disease are estimated to be 151 and 232 per million population, respectively, in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182469b91
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire preservation period reduces the incidence of delayed graft function and improves graft survival. This study evaluates whether short-term MP after cold storage (CS) is also effective. METHODS:Kidney function aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182492201
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Induction therapy is associated with excellent short-term kidney graft outcome. The aim of this study was to evaluate differences in the intragraft transcriptome after successful induction therapy using two rabbit antithymocyte globulins. METHODS:The expression of 376 target genes involved in tolerance, inf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824491aa
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:The development of kidney dysfunction is one of the most important after liver transplantation (LT). Genetic variants of pathogenetically relevant cytokines may influence the development and course of the disease. The aim of our study was to evaluate the role of transforming growth factor-β1 (TGF-β1) polymor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318242be0b
更新日期:2012-03-15 00:00:00
abstract::Hepatocyte transplantation (HT) has been performed in patients with liver-based metabolic disease and acute liver failure as a potential alternative to liver transplantation. The results are encouraging in genetic liver conditions where HT can replace the missing enzyme or protein. However, there are limitations to th...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e31823b72d6
更新日期:2012-02-27 00:00:00
abstract::World Kidney Day on March 8, 2012, provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318245f186
更新日期:2012-02-27 00:00:00
abstract:BACKGROUND:The influence of recipient body mass index (BMI) on pediatric-donor kidney transplant outcomes is unclear. We aimed to determine graft survival and functional outcomes of pediatric-donor kidneys compared with adult kidneys stratified by recipient BMI group. METHODS:Scientific Registry of Transplant Recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318241d57d
更新日期:2012-02-27 00:00:00
abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f468c
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) has an incidence of 43% at 8 years after heart transplantation with extremely limited treatment options and unclear pathogenesis. CAV constitutes a significant complication that limits the long-term survival of heart recipients. Insulin-like growth factor-1 (IGF-1) is ass...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823ec10d
更新日期:2012-02-15 00:00:00
abstract::Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f7f26
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:Vitamin D deficiency has been reported in different chronic pulmonary diseases like asthma and chronic obstructive pulmonary disease, but little is known in lung transplant recipients. METHODS:Serum 25-hydroxyvitamin D (25-OHD) levels and pulmonary function (forced expiratory volume in 1 sec [FEV(1)] %predi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823d98bc
更新日期:2012-01-27 00:00:00
abstract:BACKGROUND:Sotrastaurin (STN), a novel oral protein kinase C inhibitor that inhibits early T-cell activation, was assessed in non-human primate recipients of life-supporting kidney allografts. METHODS:Cynomolgus monkey recipients of life-supporting kidney allografts were treated orally with STN alone or in combination...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823cf92f
更新日期:2012-01-27 00:00:00
abstract:BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3182394cb3
更新日期:2012-01-15 00:00:00
abstract:BACKGROUND:Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce data compare these outcomes with nonimmunocompromised patients. METHODS:We retrospectively reviewed and compared the clinical presentation, morbidity, and mortality o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823aa528
更新日期:2012-01-15 00:00:00
abstract:INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182370db1
更新日期:2011-12-27 00:00:00
abstract:BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318238da98
更新日期:2011-12-27 00:00:00
abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182384b57
更新日期:2011-12-27 00:00:00
abstract:BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182356ca7
更新日期:2011-12-15 00:00:00
abstract:BACKGROUND:It is imperative for healthcare providers to examine Western Muslim attitudes on organ donation, because they are reluctant donors. We explored such opinion with the aid of a quantitative survey. METHODS:Voluntary completion of an anonymous survey was promoted (online and paper sampling). For a population t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318231ea17
更新日期:2011-11-27 00:00:00
abstract:BACKGROUND:One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822d87c6
更新日期:2011-10-27 00:00:00
abstract:BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822ca7ca
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822805d7
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822c6e89
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822d4e04
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantati...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822c6eb8
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists. METHODS:With the aim of investigating autoimmunity as an unrecognized cause of graft failure, we measured autoanti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822ae65f
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:The first generic tacrolimus product gained Food and Drug Administration approval in August 2009. This prospective, observational trial sought to determine the need for dose titrations and measure drug cost savings on conversion to generic tacrolimus. METHODS:Transplant recipients on stable tacrolimus doses...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/TP.0b013e31822a79ad
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182283c58
更新日期:2011-09-15 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318225281d
更新日期:2011-08-27 00:00:00
abstract:BACKGROUND:Donor organ shortage represents a major problem in lung transplantation. Donation after cardiac death could help to expand the pool of organs, but the additional period of warm ischemia after cardiac arrest aggravates primary graft dysfunction. The pulmonary endothelium of the graft constitutes an important ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318226bc6b
更新日期:2011-08-27 00:00:00